Ionizable but water insoluble or poorly soluble drug like Rosuvastatin Calcium shows poor bioavailability. Self (Micro) Emulsifying Drug Delivery System can improve bioavailability of drug. Aim of this research work is to develop self –micro emulsifying drug delivery system (SMEDDS) of Rosuvastatin Calcium. Capmul-PG8, Acconon-MC8, Tween-80 and Propylene glycol were used for development of formulation with highest efficiency. Ternary graph revealed that minimum of 65% of surfactant is required to get best desirable results. Optimized formulation shown average globule diameter of 162 nm, measured by Malvern Zetasizer. Ex-vivo study as a surrogate of in-vivo study was performed by non-everted chick ileum sac absorption model. Self-emulsifying formulation shows 30% drug diffusion/cm2 area of ileum as compare to 6% of powdered drug.
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